Abstract
ABSTRACT Objectives To investigate the impact of neck circumference (NC) in the treatment of bening prostatic hyperplasia (BPH) patients with metabolic syndrome (MtS). Additionally, we determined dose response to alpha-blockers and cut-off values for NC and waist circumference (WC), in these patients. Materials and Methods Non-randomized, open-labelled, and multi-centre study was conducted between March 2014 and September 2015. The BPH patients were enrolled and were divided into 2 groups: with MtS (Group 1; n=94) and without MtS (Group 2; n=103). Demographic data, anthropometric measurements, blood analyses, uroflowmetric parameters, post voiding residual urine (PVR), prostate volume, quality of life (QoL) index, NC and WC were recorded. Both groups were administered oral alpha-blockers and response to treatment was evaluated. Receiver-operating characteristic (ROC) curves were obtained and significant p was p<0.05 . Results In total, 197 patients were enrolled with mean age of 60.5±8.1 years. Mean NC and WC were higher in MtS patients (p<0.001). Uroflowmetry parameters and QoL indexes were comparable between groups before treatment. International prostate symptom score, uroflowmetry parameters, and QoL significant improved in Group 2 than Group 1, at 1 st and 6 th months of treatment with alpha-blockers. Success rate of treatment was significant higher in Group 2 than Group 1 (p<0.001). Cut-off values were 42.5cm and 113.5cm for NC and WC respectively, for response to alpha-blockers in BPH patients with MtS. Conclusions MtS can be related with BPH and can negatively affect the response to alpha-blocker treatment. NC can be used for predicting response to alpha-blocker treatment in BPH patients with MtS.
Highlights
Benign prostatic hyperplasia (BPH) is one of the most frequent diseases in aging men [1]
Supine waist circumference (WC) was measured at the level of the umbilicus with the patient breathing silently, and neck circumference (NC) was measured with head erect and eyes facing forward, horizontally at the upper line of the laryngeal bulge as in the World Healh Organization guidelines [9]
Uroflowmerty parameters and quality of life (QoL) index were comparable between groups except body mass index (BMI), NC, and WC were significant higher in Group 1 than Group 2 (p
Summary
Benign prostatic hyperplasia (BPH) is one of the most frequent diseases in aging men [1]. Alpha-blockers are the first choice of medical treatment of BPH [2]. It was established that MtS is one of the causing factors for the development of BPH in aging men [5]. MtS consists of some metabolic risk factors on individuals [6]. The presence of three of the following risk factors constitute MtS: blood pressure (BP) ≥130/85mmHg, fasting blood glucose (FBG) ≥110mg/dL, waist circumference (WC) ≥102cm, High-density lipoprotein (HDL)-cholesterol
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