Abstract
ObjectivesTo characterise geographical distribution and time trends of chronic kidney disease (CKD) mortality in the context of the epidemic of Mesoamerican nephropathy (MeN), likely related to occupational heat stress and...
Highlights
chronic kidney disease (CKD) seemed high already four decades ago in the province. These findings are pertinent for etiologic research
We examined lung cancer risk among bricklayers within SYNERGY, a large international pooled analysis of case-control studies on lung cancer and the joint effects of occupational carcinogens
For men ever employed as bricklayers we estimated odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for study centre, age, lifetime cigarette smoking history, and employment in occupations with exposures to known or suspected lung carcinogens
Summary
Bricklayers may be exposed to several lung carcinogens, including crystalline silica and asbestos. Previous studies reported an excess of lung cancer among these workers. We examined lung cancer risk among bricklayers within SYNERGY, a large international pooled analysis of case-control studies on lung cancer and the joint effects of occupational carcinogens (http://SYNERGY.iarc.fr). Method The pooled dataset included 15 608 cases and 18 531 controls from 22 centres in Europe, Canada, Hong Kong, and New Zealand. For men ever employed as bricklayers we estimated odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for study centre, age, lifetime cigarette smoking history, and employment in occupations with exposures to known or suspected lung carcinogens. ORs were still elevated after additional adjustment for education and in analyses using blue collar workers as referents
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