(020) Post-SSRI/SNRI Sexual Dysfunction: A review

Abstract

Abstract Introduction Post-SSRI-SNRI Sexual Dysfunction (PSSD) is conceptualized as distressing issues with sexual function/pleasure that emerge with SSRI/SNRI initiation and persist after SSRI/SNRI termination and depression remission, and that are not due to other contributors. Although there is increasing recognition of PSSD in clinical practice and research, it is not well understood, researched, or managed. Objectives To provide an overview of SSRIs/SNRIs and their side effects (sexual and otherwise), to present and evaluate the working definition of PSSD, to describe current etiological theories and management strategies of PSSD, and to highlight future directions. Methods A review of the literature was undertaken in order to understand the current conceptualization of PSSD. Particular attention was paid to sexual and nonsexual side effects of PSSD as well as etiological theories and management strategies. Results SSRIs and SNRIs often lead to sexual side effects, which may affect treatment adherence and compliance. A small subset of individuals may develop PSSD, in which distressing sexual dysfunction persists after termination of the SSRI/SNRI and can last months to years. Nonsexual side effects (e.g., cognitive, emotional) have also been reported, and the desire for informed consent as well as collaborative health care has been reported by those affected. PSSD has been recognized as a medical condition by the European Medicines Association since 2019. Conclusions PSSD is increasingly recognized as a potential side effect of SSRI/SNRI use, and concerted collaboration and effort is needed in order to comprehensively understand this condition and its management. Disclosure No.