02 Studying the Erectile Function Impact of Vitamin D Therapy in Patients with ED: Interim Analysis From A Randomized Controlled Study

Abstract

Vitamin D deficiency (VD) has been associated with increased cardiovascular disease risk. Several studies have reported a link between ED and VD. We aimed to investigate if correcting vitamin D levels improved erectile function in ED patients with concomitant VD. We prospectively sequentially assigned 200 consecutive vitamin D deficient patients diagnosed with vasculogenic ED, based on duplex Doppler ultrasound, into two groups. Group A received tadalafil 5 mg daily alone; Group B received vitamin D 5000 iu orally daily in combination with tadalafil 5 mg daily; the intervention was for 6 weeks. Data collected pre and post therapy included the IIEF erectile function domain (IIEF-6), erection hardness score (EHS) and a sexual encounter profile (SEP). A total of 174 patients completed the study, 81 in group A and 93 in group B. Median age was 50 overall, 56 (42, 65) in group A and 47 (35, 55) in group B (p<0.01). Prevalence of comorbidities were (group A vs group B): diabetes 63% v 32% (p<0.01); hypertension 56% vs 27%; cigarette smoking 38% vs 27% (p=0.14); vitamin D level 22 vs 15 (p,0.01). Baseline median IIEF-6 and EHS scores were: 13 vs 16 (p<0.01) and 2 vs 3 (p<0.01). End of treatment data are presented in Table 1. The median changes for IIEF-6 were 3 vs 5 (p<0.01); for vitamin D level 0 vs 17 (p<0.01).