0194 Analysis of clinical and electroencephalographic features in patients with early and late onset benign childhood epilepsy with occipital paroxysms

Abstract

Objective To compare the clinical and electroencep halographic features and therapeutic responses between early onset benignoccipital seizure susceptibility syndrome (EBOS) and late onset childhood idiopathic occipital seizure (LOS). Methods Thirty patients were diagnosed as benign childhood epilepsy with occipital paroxysms defined by the Commission of the International League Against Epilepsy (ILAE) in 1989. Twelve patients of them were characterized as having EBOS and 18 patients having LOS as described by ILAE proposal in 2001. The differences between EBOS and LOS with regard to age of onset, clinical data of seizures, EEG changes and therapeutic responses were studied. Results The mean age of onset of EBOS patients [(5.6±2.4) years] was significantly younger than that in LOS [(12.1±2.7) years]. Compared with LOS patients, EBOS patients had less frequent seizures, longer seizure duration, and more nocturnal seizures. LOS patients had more visual symptoms (including hallucinations) and tended to secondary generalized tonic-clonic seizures that occurred mostly in daytime. The interictal EEG showed the spike- and sharp-show waves mainly in the occipital, and the waves were more typical and limited in EBOS patients than those in LOS ones. The discharges in the occipital of LOS patients were easy to generalization in EEG. EBOS was controlled well by AED monotherapy, but the monotherapy was ineffective in 5 LOS patients (27.8%). Conclusion To distinguish EBOS from LOS, detailed description and analysis on the age of onset, the frequency and duration of seizures, visual symptoms, EEG changes and therapeutic responses are essential.