019 The Robust Angiogenic Response to Hindlimb Ischemia in Mice Yields a Microvasculature That is Structurally and Functionally Abnormal

Abstract

(SRPH) after five years. METHODS: Body mass index and WC were assessed in 538 apparently healthy males and females between 30 and 65 years of age who were part of the Multicultural Community Health Assessment Trial (M-CHAT). Participants were assessed for baseline BMI and WC and followed for five years and assessed for SRPH (using the EuroQOL-5D questionnaire). The EuroQOL questionnaire asked participants to rate their current state of health out of a maximal score of 100, with 100 being the best health they have had in their life. Bivariate correlation analyses were used to explore the relationships between and baseline BMI and baseline WC with five year SRPH. The analysis of variance (ANOVA) was used to compare SRPH scores at year five among normal, overweight and obese individuals based on baseline BMI. A T-test was used to compare SRPH scores at year five between high and low abdominal obesity based on baseline WC. A WC at or above 102 cm for men and 88 cm for women was used for the threshold. Linear regression was used to explore the separate association between baseline BMI or WC and five-year SRPH adjusted for age, sex, smoking status and ethnicity. RESULTS: Baseline BMI (r -0.104, p 0.05) and WC (r 0.104, p 0.05) were negatively correlated with QOL score at five year follow-up. Baseline BMI had no significant effects on five-year QOL scores (p 0.09). Participants with a high WC at baseline had lower five-year QOL scores compared to participants with low WC at baseline (X 76, SE 1 vs. X 79, SE 1, p 0.05). Baseline WC was a negative predictor of SRPH scores at year five ( -0.139, p 0.05) adjusted for age, sex, ethnicity, and smoking status. CONCLUSION: While BMI, as an overall indicator of obesity, was not associated with participant perceived health, WC was, such that increased WC was a predictor of decreased perception of health. This further indicates the detrimental impact that central obesity has on individuals.