Abstract
rectal temperature was measured again before and until 4 h after the female rats received 4% pilocarpine i.p. The temperature measures obtained during the pilocarpine injection of OVX (n= 10) female rats were compared with NO OVX (n= 18) female rats submitted to the pilocarpinemodel. The female rats that presented status epilepticus (SE) and those that did not present status epilepticus (NO SE) were compared. Results: Female Wistar rat temperature did not change significantly during the estrous cycle. Nevertheless, these female rats showed a significant temperature reduction after the ovariectomy procedure (p b 0.01). Besides that, NO OVX female rats showed a significantly higher rectal temperature (p b 0.01) before pilocarpine injection compared with the OVX group and still presented significantly lower rectal temperature (p b 0.05) until 4 h after pilocarpine injection. At 1 h after the pilocarpine injection, the significance between the two groups was higher, p b 0.01. Our preliminary results also show that 60% of OVX female rats presented SE after receiving pilocarpine injection, 30% died after a tonic–clonic seizure, and only 10% did not show SE. In NO OVX female rats, only 22% showed SE after pilocarpine injection, and 78% did not. Discussion/conclusions:Our previous results confirm that the absence of reproductive hormones alters the gonadal–hypothalamic–pituitary axis, and this may lead to changes in the temperature that might influence the brain response to pilocarpine and protect it from seizures.
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