Abstract
Human skin harbours a large proportion of the resident memory T (Trm) cells of the body. Trm cells promote immune homeostasis and exert anti-microbial and anti-cancer function in tissue. We recently demonstrated that skin Trm cells are permanently depleted in people living with HIV (PLWH) with a low nadir and possibly replaced by blood-derived T cells. We linked the loss of Trm cells in PLWH with the increased risk of developing cutaneous and mucosal cancer. The T-cell receptor (TCR) diversity analysis with next generation sequencing might give new insights into the biology of skin Trm cells at homeostasis and in HIV.
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