Abstract
The human skin harbors a heterogenous pool of cytotoxic tissue-resident memory T (TRM) cells seeded during infections and inflammation. TRM cells are retained at the site of viral infections and provide local immunity. These cells persist for years in the skin after bone marrow transplantation but circulating ex-TRM cells indicate several potential fates. Here, we explored the clonal relationships between human T cells in different skin compartments and circulation. 10x Genomics 5 prime immune profiling coupled with feature barcoding technology was employed to investigate the clonal relationship, transcriptomic and proteomic profiles of single T cells sorted from blood, subcutis, dermis, and epidermis.
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