0124: Evaluation of cannabis abuse and epidemiology in 61 young adults aged less than 35 years old hospitalized for acute coronary syndrome

Abstract

Evaluation of cannabis abuse and epidemiology in 61 young adults aged less than 35 years old hospitalized for acute coronary syndrome. before the age of 35, acute coronary syndrome (ACS) are rare. Their epidemiological characteristics are unique. this is a retrospective single-center study at the University Hospital of Brest of patients aged less than 35 years old hospitalized between 01/01/1998 and 31/12/2010 for ACS with or without ST segment elevation. The initial clinical and angiographic data were collected frommedical records. In a second phase, a questionnaire was sent to everypatient to determine their cannabis use at the the time of the onset ofthe ACS. 61 patients were included (89,6% male). The mean age of the patients was 31.04+ – 3 years old. Conventionnal cardiovascular risk factors were active smoking in 86.9% of cases, coronary heredity in 40.9% cases and dyslipidemia in 40.9% of patients. There was history of stressin 37% of cases and a regular cannabis use in 22.9% of patients. The STelevation ACS accounted for 68.8% of cases. They occurred during an effort in 14.8% of cases and patient were often inaugural (68.8%). In most of cases, patients had single vessel disease (61.7%), multivessel disease was found in 24.1% of cases. The left anterior descending (LAD) was affected in 58.6% of cases, the circumflex artery (CX) in 17% and right coronary artery (RCA) in 24.6% of cases. The coronarography was normal in the ten patients who were significantly more often cannabis smokers (50%, p<0.05). Angioplasty was the most common method of revascularization (62.7%) with bare metal stents for 34 patients (55%).no patient died during the hospitalization, complications (mainly arrhythmias) occurred in 19.6% of cases. ACS in the young have specific epidemiological characteristics. Cannabis users represent 22.9% of this population.