Abstract
Dupilumab, a therapeutic antibody that blocks the eczematous type 2 immune response in atopic dermatitis (AD), has shown efficacy in many clinical trials and real-life observational studies. Besides blepharitis and conjunctivitis, the de novo appearance of head-neck dermatitis is recognized as a distinct side effect, occurring in up to 10% of patients at any time after dupilumab initiation. Histopathological features distinct from conventional AD such as psoriasiform hyperplasia or increased numbers of ectatic capillaries suggest a drug effect, but exact underlying mechanisms remain largely unknown.
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