Abstract
It is commonly accepted that immune tolerance to self-antigens occurs in the thymus and secondary lymphoid organs. Despite the presence of rich immune microenvironments in non-lymphoid organs, such as skin and gut, it is currently unknown if self-tolerance is actively maintained in these tissues. We developed a novel technique to induce genetic recombination only in regulatory T cells (Tregs) that reside in skin. Cell lineage-tracing revealed that skin Tregs undergo significant attrition and replenishment during their natural life cycle.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
