0102 : Frequency and outcomes of hyponatremic ambulatory patients with chronic heart failure

Abstract

Hyponatremia – lowering of sodium in blood serum below 135 mmol/l – is a frequent disorder of electrolyte metabolism in patients with chronic heart failure (CHF). It is an established predictor of adverse outcomes in hospitalized patients with reduced ejection fraction. To evaluate the incidence of hyponatremia in ambulatory patients diagnosed with chronic heart failure in order to establish a correlation with the risk factors, evolution and prognosis. We examined the prevalence, risk factors, and long-term outcomes of hyponatremia (serum sodium =< 135 mEq/L) in ambulatory HF with reduced EF The cohort consisted of 1240 admitted in the therapeutic unit of heart failure (TUHF) between 2006 and 2014. Hyponatremia was present in 19.6%. Mean serum levels of natremia and were 131.3 meq/l. Hyponatremia was associated with male sex, diabetes, strock attack, coronary heart disease. Compared with normonatremic patients, those with hyponatremia had lower systolic blood pressure and lower functional capacity during six – minute walk. Also, Hyponatremia was associated with cardiac decompensation, diastolic dysfunction (p=0.014), severe renal insufficiency and higher doses of diuretics (p<0.0001), whereas beta-blockers were inversely associated (P<0.0001). Patients with heart failure and hyponatraemia on showed a higher risk of long-term morbidity than patients without.