0102 Are there associations between intraindividual variability in sleep and mental health among adolescents reporting alcohol use?

Abstract

Abstract Introduction Considering the increasing number of studies that report on ecological momentary assessment by uses of sleep diary and actigraphy, it may also be valuable to consider the relationship between fluctuations that exists in sleep measures on adolescent health outcomes. Above the impact of mean sleep measures, intraindividual variability (IIV) in sleep provides information on the degree to which daily variations or fluctuations in sleep/wake patterns are occurring and may prompt important cues to adolescents’ health outcome. The present study examined the objective IIV in sleep and its relationship to their sleep and mental health outcomes among adolescents with history of alcohol use. Methods The study analyzed 8 days of wrist actigraphy data from 72 high school students reporting prior alcohol use (58.3% female; mean age 17.0 years). Bayesian variability method using varian (R package) was performed to calculate IIV in total sleep time (TST), time in bed (TIB), midpoint sleep, bedtime, and risetime. Participants also completed Pittsburgh Sleep Quality Index (PSQI), Cleveland Adolescent Sleepiness Questionnaire (CASQ), Inventory of Depressive Symptomatology (IDS-SR-30), Chapman’s Inventories – Social Anhedonia (CHAPSAS), and Rutgers Alcohol Problem Index (RAPI). Multiple linear regression models were adjusted for biological sex, age, and the sum of alcohol drinks in the past 3 months. Results Participants reported average of 18.52 (SD=23.10) total drinks consumed over the past 3 months. IIV in TST, TIB, and risetime were associated with lower sleep quality (B=3.04, 95% CI, 0.02, 7.39, p< 0.05 for IIV in TST; B=2.87, 95% CI, 0.39, 5.88, p< 0.05 for IIV in TIB; and B=2.74, 95% CI, 0.57, 6.19, p< 0.05 for IIV in risetime, respectively). There was no statistically significant association between IIV of sleep measures and excessive daytime sleepiness or mental health outcomes such as social anhedonia, depressive symptoms, and problematic alcohol use. Conclusion Greater fluctuation in TST, TIB, and risetime were negatively associated with overall sleep quality. Our findings add to a growing body of research on IIV in sleep/wake patterns and clinical implications. Future studies should explore the prospective relationship between variability in sleep and other various health outcomes. Support (if any) NIH/NIAAA R01AA025626 (Hasler); Sleep Research Society Foundation Mentor-Mentee Award (Kwon)