術前使用0.1% Diclofenac Sodium或0.1% Indomethacin對白內障手術之影響

Abstract

Fifty-nine eyes of fifty-one patients scheduled for extracapsular cataract extraction and posterior chamber intraocular lens implantation were randomly, double-blindly assigned to received either (1) pretreatment with one drop of diclofenac sodium 0.1 % four times per day for the day before surgery plus one drop of diclofenac sodium 0.1% every 30 minutes for four doses, beginning 2 hours before surgery along with the dilating drops; (2) pretreatment with one drop of indomethacin 0.1% with the same protocol as the previous prescribed; (3) pretreatment with one drop of normal saline as a placebo with the same protocol. The pupil size was measured before surgery and before IOL implantation. Aqueous cells and flare were assessed and intraocular pressure was measured on the first postoperative day. All surgeries were performed by the same surgeon. On the first postoperative day, anterior chamber inflammation was more severe in control group than experimental groups. The difference between groups 1 and control group was statistically significant (p＜0.05). But the difference between experimental groups was not statistically significant (p＞0.05). There was no statistically significant difference in the amount of surgical-induced miosis and in the members of eyes with raised post-operative intraocular pressure among these three groups. We concluded that the pretreatment with an NSAID, either diclofenac sodium 0.1% or indomethacin 0.1%, before extracapsular cataract extraction with intraocular lens implantation can reduce the early postoperative anterior-chamber inflammation.