0097 : Influence of dyslipidemia on clinical characteristics in heart failure patients. Series of 583 cases

Abstract

Dyslipidemia is a high risk factor of heart disease. Among heart disease, the prevalence of heart failure is increasing in recent years. We aim to investigate the association between lipid profile and age, gender, clinical and echocardiographic characteristics and the influences of dyslipidemia on heart failure. This retrospective study including 583 patients (72 years, 338 were male) admitted in the therapeutic unit of heart failure (TUHF). All patients underwent measurement of serum lipid profiles. They were divided into two groups based on combining dyslipidemia or not. Clinical characteristics, biochemical data and echocardiography were analyzed in both groups. There were 246 (45%) patients diagnosed with dyslipidemia in our study. Mean serum levels of total cholesterol and triglycerides were 2.31g/l and 2,59g/l respectively in group with dyslipidemia. Young age, diabetes, hypertension, strock attack, and coronary heart disease were associated with dyslipidemia (p value <0.001). Patients with dyslipidemia had a significantly diastolic dysfonction (p=0.035) and lower functional capacity during six - minute walk. Higher level of glucose was also noted in dyslipidemia population. No sex-related difference in dyslipidemia and nondyslipidemia (p=0.17) and no correlation between dyslipidemia and cardiac decompensation were found (p=0.36). Dyslipidemia is associated with others risk factors of coronary heart disease. These results demonstrate a correlation between functional capacity, left ventricular diastolic dysfunction and dyslipidemia.