Abstract
Systemic sclerosis (SSc) is a chronic autoimmune disease causing vasculopathy and fibrosis in the skin and vital organs. Following an inflammatory reaction, fibroblasts in the connective tissues become activated myofibroblasts and secrete excessive amounts of ECM related proteins, such as collagen, creating fibrosis. Many studies have been carried out in fibroblasts in culture, however, the information obtained remains limited due to high potential heterogeneity of these fibroblasts. We therefore used single cell RNA sequencing to better understand fibroblast heterogeneity in SSc to search for potential new therapeutic targets and new biomarkers.
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