Abstract
Regulatory T cells (Treg) are a critical immune component guarding against excessive inflammatory responses, but current understanding of Treg heterogeneity and function in non-lymphoid tissue in humans is limited. In this project we are characterising unique types of Treg signatures in the context of tissue-confined inflammatory responses in human skin and gut. We are hypothesising that a common ground between these pathologies may be found in a dysfunction of immune regulation. To investigate this, we are utilizing transcriptomic, phenotypic and metabolomic methods, using an integrative bioinformatical approach of single-cell (sc) sequencing data and global metabolomic screens of Tregs from blood and tissue of patients with chronic inflammatory diseases.
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