Abstract
IL-9 is a common gamma-chain cytokine, for which a range of pleiotropic functions have been proposed. However, an overarching role in humans remains elusive. IL-9 and its receptor, IL-9Rα, are specifically expressed by pathogenic TH2 cells (pTH2) residing in the skin, suggesting an important function of autocrine IL-9 signals in cutaneous immunity and allergy. Yet, the regulation of IL-9Rα expression on pTH2 cells and the auto- and paracrine functions of IL-9 remain incompletely understood. Here, we confirmed that IL-9Rα is strongly enriched in CRTh2+ memory TH2 cells isolated from blood and skin.
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