Abstract

Background Time-to-reperfusion, electrocardiographic and angiographic parameters are of prognostic relevance in ST-elevation myocardial infarction (STEMI) patients. We sought to evaluate predictors of Infarct size (IS) and presence of microvascular obstruction (MO) using delayed hyper-enhancement magnetic resonance imaging (CMR). Methods and results We analyzed 128 consecutive STEMI patients reperfused by primary PCI within 12 hours after symptom onset. IS and MO were assessed by delayed hyper-enhancement MRI as percentage of LV mass, 4±2 days after acute MI. Reperfusion times, TIMI-flow grades pre and post PCI, 90 min ST-segment resolution, cardiovascular risk factors, Killip-class, and infarct location were assessed. In patients with TIMI flow 0-1 before PCI, IS was significantly higher compared to patients with TIMI-flow 2-3 (22±12% versus 16±15%; p Conclusions The pre-PCI TIMI flow, infarct location, Killip class and ST-segment resolution are the strongest predictors of IS and extent of MO as assed by delayed Hyper-enhancement MRI. CMR allow for strong evaluation in STEMI patients, giving important information regarding prognostic.

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