Abstract
Cytotoxic T lymphocyte (CTL) has been found to be activated by cutaneous dendritic cell (DC) in inducible skin-associated lymphoid tissue (iSALT) in a murine contact hypersensitivity (CHS) model. Cutaneous DCs are classified into Langerhans cell (LC), conventional DC1 (cDC1), conventional DC2 (cDC2) and monocyte-derived DC (MoDC); however, which DC subsets activate CTL within iSALT during the elicitation phase of CHS has remained unclear. To clarify this, we used Langerin-diphtheria toxin receptor (DTR), XCR1-DTR and CD301b-DTR mice to deplete LC, cDC1 and cDC2, respectively.
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