0057 The Impact of Cortical Oxygenation During Sleep-Disordered Breathing on Cognition

Abstract

Abstract Introduction Untreated sleep-disordered breathing (SDB) has been reported as a common risk for dementia. However, the association between current SDB parameters (i.e., AHI) and cognition is not straightforward. To examine the impact of cortical oxygenation during SDB on cognition in older adults, we measured the coherence of oxyHb and SpO2 during SDB, in which a higher level can represent less protection against systemic hypoxia, is associated with cognition in older adults. Methods Thirty-eight community-dwelling, healthy older adults without dementia (20 women) were recruited. The mean and standard deviation (SD) of age was 72.6±6.4years. All participants underwent comprehensive neuropsychiatric evaluation of short and long-term verbal memory(Wechsler Memory Scale & Rey Auditory Verbal Learning Test), Executive Functioning (Delis-Kaplan Executive Function System), verbal naming abilities (Boston Naming Test), and visuo-spatial ability (Judgment of Line Orientation). We performed a simultaneous PSG and NIRS recording overnight at the participants’ houses. We measured the mean max coherence of oxyHb and SpO2 and analyzed its correlation to cognition. Results The mean and SD of total sleep time, N1, N2, N3, and REM were 392.8±71.8 min, 65.5±60.3min, 210.7±68.5min, 53.1±30.9min, and 63.5±25.4 min. The mean and SD of AHI were 21±17.4 events/hour. The mean and SD of the max coherence ratio were 0.78±0.10. Linear regression analysis found higher coherence of oxyHb and SpO2 to be significantly correlated, after Bonferroni Correction, with a poorer score on the age-corrected BNT score (t = -3.174, p = .003), covaried for gender and education. Conclusion Higher coherence of oxyHb and SpO2 during SDB may predict poorer verbal naming abilities in older adult Support (if any) National Instutite on Aging