Abstract
IL-9 is a pleiotropic cytokine, for which an overarching role in humans remains elusive. Recent research shows that Interleukin 9 (IL-9) and its receptor, IL-9R, are predominantly expressed by skin-tropic T helper 2 (TH2) cells. This hence suggests that autocrine or paracrine IL-9 signals play an important role in cutaneous immunity and allergy. Yet, the mechanism of action remains incompletely understood. Here, we aimed at deciphering the effect of IL-9 on TH cells in allergic skin inflammation.
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