Abstract
Methotrexate (MTX), a first-line systemic agent for the therapy of psoriasis, is often associated with adverse effects. Localized transdermal delivery of MTX using dissolving microneedles (MNs) was demonstrated to be both more efficacious and better tolerated than oral administration in our previous work. This study aims to elucidate the detailed therapeutic mechanism of MTX-loaded MNs and to explore whether topical MTX treatment can affect the formation of skin lesion at distant parts of the body while attenuating local inflammation.
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