002 Skin-resident memory T cells are poised for systemic Th2/Th17-driven inflammation and may re-seed at distant sites during graft-versus-host disease

Abstract

Skin-resident memory T cells are thought to be non-circulating cells providing rapid recal responses against outside pathogens. Recent observations in humanized mouse models indicate that a subset of tissue-resident memory T cells (Trm) may exit the skin and form a discrete circulating T cell population in the blood. To explore the existence of a skin-derived re-circulating Trm population in humans, we characterized circulating T cells with a skin Trm phenotype in the blood of patients after allogeneic hematopoietic stem cell transplantation (HSCT).