Abstract
TH9 cells, a subpopulation of TH2 cells, are crucial mediators of allergic skin inflammation. They are characterized by expression of IL-9/IL-9R and rely on the transcription factor PPARγ for full effector function. The functional role of PPARγ in TH9 cells, however, remains unknown. Pathway analysis of RNA-seq data from PPARγ-inhibited TH9 cells revealed concerted downregulation of genes associated with T cell activation, glucose metabolism, and aerobic glycolysis. Accordingly, TH9 cells featured a higher glycolytic activity as compared to TH1 and TH2 cells.
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