Abstract
Danio Rerio (zebrafish) is a relatively new model subject that is more and more widely used in different biomedical studies, including studies of the central nervous system (CNS) and search for new therapeutical agents. The number of studies dedicated to the zebrafish neurophysiology is rapidly increasing, and this growth surpasses in relative numbers all other model organisms in the biomedical field. The popularity of this model is ensured by the relative ease of use, thoroughly studied physiology, high genetic homology with humans, fast development, and low cost of the studies. Here, we discuss the current role of zebrafish in the field of translational neurobiology, and their potential use in combination with the recent biological techniques. Despite the fact that the screening and description of the effects of known psychoactive compounds on zebrafish gets actively adopted for practical use (in Russia as well), the studies of the diseases on this model remain limited. We outline the importance of the studies of CNS pathogenesis in zebrafish due to its high potential as a study subject that is evolutionally conservative and relatively easy to use, which can facilitate the identification of the main biomarkers of the heterogenous diseases.
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