Abstract
Abstract Vitex trifolia L. is a full grown fruit of Vitex rotundifolia L. (Verbenaceae). It has been used fortreating headache, dizziness, toothache and removal of fever as a traditional medicine in Korea. V. trifolia(500 g) were extracted three times with 80% aqueous MeOH at room temperature. The MeOH extract (38 g)was successively partitioned with n-hexane, EtOAc, n-BuOH and H 2 O. Both n-hexane and EtOAc fractionsshowed more than 80% antifungal activity in vivo against several plant pathogens at 2000 ppm. Successiverepeated silica gel, Sephadex LH-20, preparative TLC, and preparative HPLC of these fractions led toisolation of three compounds. Using mainly mass spectroscopy and nuclear magnatic resonance (NMR)spectroscopy, their chemical structures were determined as agnuside(1), chrysosplenol B(2), and artemetin(3).Compound 2 was isolated for the first time from V. trifolia. Study on in vitro and in vivo antifungal activitiesof the isolated compounds is in progress. Key words Vitex trifolia L., Agnuside, Chrysosplenol B, Artemetin
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