Abstract
As shown in our previous paper, V, neither trimethylamine (TMA) nor trimethylamine oxide (TMAO) was described to have any recognizable synergism on the action of histamine or “saurine” to contract intestine or uterus of guinea pigs. This paper also deals with the effect of those substances when added to histamine or “saurine” tested by shock symptoms in guinea pigs, skin reaction in rabbits and lethal dose for mice (LD50). The addition of TMA or TMAO resulted in no appreciable change in the action of histamine of “saurine” Per se in each experiment. Therefore, the presence of TMA or TMAO, if any, coald not be regarded to stand as a cooperative factor to either histamine or “saurine” in a foodstuff responsible for allergylike food poisoning.
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