Характеристика параметров угла передней камеры на фоне многократных интравитреальных инъекций анти-VEGF препаратов

Abstract

Purpose. Using optical coherence tomography of the anterior segment of the eye (ASOCT) to identify dynamic changes in the parameters of the anterior chamber angle (ACA) produced by multiple intravitreal injections (IVI) of anti-VEGF drugs in the treatment neovascular form of age-related macular degeneration (nAMD). Material and methods. 30 patients were included in the study. Using the Revo NX tomograph (Optopol, Poland), the main parameters of the anterior chamber angle in the meridian from 0–180° were studied: the angle opening value (in degrees °), the angle opening distance (this indicator is the distance between the posterior surface of the cornea and the iris in 500 and 750 µm from the scleral spur (AOD500, AOD750; angle opening distance, mm)). The study was carried out before IVI, one month after 1 IVI, one month after 3 IVI, one year after the start of treatment. Results. An intergroup analysis revealed a narrowing of the ACA as well as a decrease in the opening distance of the AOD500 angle both from the nasal and temporal sides one month after three IVI anti-VEGF drug compared with the start of treatment (p < 0.05). A year later, against the background of antiangiogenic therapy, a decrease in all parameters of the ACA was revealed: the magnitude of the angle opening, the angle opening distance AOD500, AOD750 both from the nasal and temporal sides (p < 0.05). A greater number of IVIs was associated with a greater narrowing of the ACA one year after the start of treatment on the temporal (R^2 = 0.424, p = 0.02) and nasal (R^2 = 0.37, p = 0.049) sides. Conclusions. There was a statistically significant narrowing of the ACA from the nasal and temporal sides in the 0–180° meridian according to AS-OCT produced by IVI of anti-VEGF drugs. Keywords: anterior chamber angle, intraocular pressure, anti-VEGF therapy