Abstract
We have cloned and characterized γ-tubulin genes from both X. laevis and S. pombe, and partial genes from maize, diatom, and a budding yeast. The proteins encoded by these genes are very similar to each other and to the original Aspergillus protein, indicating that γ-tubulins are an ubiquitous and highly conserved subfamily of the tubulin family. A null mutation of the S. pombe gene is lethal. γ-tubulin is a minor protein, present at less than 1 % the level of α- and β-tubulin, and is limited to the centrosome. In particular, γ-tubulin is associated with the pericentriolar material, the microtubule-nucleating material of the centrosome. γ-Tubulin remains associated with the centrosome when microtubules are depolymerized, suggesting that it is an integral component that might play a role in microtubule organization.
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