Abstract
The aim of this study was to investigate the TLR2 gene expression in the surface epithelium of the upper airway mucosa. 210 surgical samples of nasal and sinonasal mucosa (inferior turbinate mucosa, the mucosa of the middle nasal passage, polyps), tympanic and mastoid cavity and laryngeal mucosa, adenoids, palatine tonsils were investigated. Estimation of TLR2 and beta-actin gene expression by levels of the corresponding mRNA synthesis was performed by real-time PCR. The expression of TLR2 gene was detected in the all mucosal tissue specimens. The lowest levels of TLR2 gene expression was detected in the samples of adenoids and tonsillar epithelium (p < 0.01; Mann-Whitney test), laryngeal mucosa (p < 0.02). The highest levels of TLR2 gene expression was detected in sterile middle ear pathology — otosclerosis (p < 0.02). Probably, low levels of TLR2 gene expression in the surface epithelium of the highly colonized upper respiratory mucosa serve as one of the ways to protect against the development of excessive local inflammation.
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