Abstract
LIVER transplantation (LT) is an accepted therapy for end-stage liver diseases. In this condition, 5% to 15% of liver grafts suffer primary nonfunction (PNF) and up to 30% have initial poor function (IPF). Both cases consist of different clinical manifestations of preservation injury (PI). PI is related to several factors and begins even before the procurement, due to either a possible preexisting liver disease of the donor or the injury associated with brain death; it can be related to harvesting, to cold preservation, or to reperfusion injury. The latter is triggered by free radical release, and leads to cellular activation and severe cell damage for both parenchymal and nonparenchymal cells. Some drugs, called scavengers, are capable of reducing the deleterious effect of free radicals. In the present study, we evaluated the protective effect of a-tocopherol, a free radical scavenger, on the reperfusionrelated hepatocyte injury in rat livers.
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