Abstract
Pyrethroid insecticides exert their toxic actions by prolonging the open time of individual neural sodium channels. α-Tocopherol (vitamin E) has recently been shown, via a patch clamp analysis of rat cells, to antagonize this action. To determine if α-tocopherol could provide protection against pyrethroids in vivo we examined the toxicity of a common pyrethroid (permethrin) against house flies and German cockroaches. Tocopherol antagonized the toxicity of permethrin by 4.3- and 6.6-fold in house flies and German cockroaches, respectively. α-Tocopherol also antagonized permethrin toxicity by 6.2-fold in a kdr-type resistant strain of German cockroach (i.e. strain having an altered form of the para-homologous sodium channel). These studies indicate α-tocopherol is an effective antagonist of permethrin in vivo, protecting insects that have either normal or kdr-type sodium channels.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
