Abstract
Purpose. To reveal the association of polymorphisms within the genes encoding Toll-like receptors (TLRs) with carbohydrate metabolism disorders (CMDs) in patients with coronary artery disease (CAD). Materials and methods. Study sample included 292 patients with coronary artery disease. We investigated 8 polymorphisms within 4 genes: TLR1 (rs5743551 and rs5743611), TLR2 (rs3804099 and rs5743708), TLR4 (rs4986790 and rs4986791), TLR6 (rs3775073 and rs5743810). Results. T allele of the rs4986791 (Thr399Ile) polymorphism and G allele of rs4986790 (Asp299Gly) polymorphism within TLR4 gene are significantly associated with decreased risk of CMDs, whereas G allele of rs5743611 polymorphism within TLR1 gene is significantly associated with higher risk of CMDs. Conclusion. We found significant associations of the polymorphisms within the genes encoding TLRs (T allele of rs4986791 polymorphism and G allele of rs4986790 polymorphism within TLR4 gene and G allele of rs5743611 polymorphism within TLR1 gene) with CMDs in patients with CAD.
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