Abstract
Introduction. Environment, lowered physical activity and low standards of living lead to the increase of incidence of diseases in the population of Ukraine, in particular, pathologies of prostate in men. Creation of plant-derived medicines for the treatment of the abovementioned pathologies is of great interest nowadays. Phytomedicines possess low toxicity andare characterized by high safety level, absence of negative action towards sexual function, possibility of long-term usage in complex therapy. Phytoremedies with prostate protective activity usually include extracts of plants that show anti-inflammatory, immune stimulating, spasmolytic, diuretic, antioxidant, antitumor activity. Field pennycress belongs to the prospective sources of obtaining prostate protective remedies. Field pennycress (Thlaspiarvense L.) from cabbage family (Brassicaceae) shows the abovementioned types of activity, thus it is used for the prophylaxis and treatment of benign prostate hyperplasia. Among biologically active compounds of herbal medicines a certain role in reaching therapeutic effect play steroidal compounds, which show prostate protective, cytostatic activity. Thus, for a more detailed research on field pennycress herb its thick extract was obtained, in which the qualitative composition and quantitative content of steroidal compounds was studied.Research Methods. Gas chromatography was used for the phytosterols’ study in the thick extract of field pennycress herb.Results and Discussion. 3 compounds were identified using the gas chromatography method: stigmasterol, sitosterol and lanosta-9(11),24-diene-3-ol acetate and their quantitative content (0.12 mg/kg, 0.16 mg/kg, 0.29 mg/kgrespectively) was determined in the thick extract of field pennycress herb.Conclusions. The obtained results might be used at quality control methods development for the thick extract of field pennycress herb.
Highlights
Environment, lowered physical activity and low standards of living lead to the increase of incidence of diseases in the population of Ukraine, in particular, pathologies of prostate in men
The most wide-spread factors that have negative impact on sexual function in men are inflammatory processes, hormonal and destructive chang es in prostate gland. In such pathologies phytomedicines characterized by high safety level, absence of negative action towards sexual function, possibility of long-term usage in complex therapy [1,2,3]
Among biologically active compounds of herbal medicines steroidal compounds play a certain role in reaching therapeutic effect
Summary
O. I. Panasenko1, G. S. Tartynska2, V. V. Hutsol3 ZAPORIZHZHIA STATE MEDICAL UNIVERSITY1 NATIONAL UNIVERSITY OF PHARMACY2, KHARKIV M. PYROHOV VINNYTSIA NATIONAL MEDICAL UNIVERSITY3 THE STUDY OF STEROIDAL COMPOUNDS IN THICK EXTRACT OF FIELD PENNYCRESS HERB (THLASPI ARVENSE L.)
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