γδ TCR Recognition of MR1: Adapting to Life on the Flip Side

Benjamin E Willcox,Fiyaz Mohammed,Carrie R Willcox

doi:10.1016/j.tibs.2020.03.012

Benjamin E Willcox, Fiyaz Mohammed + Show 1 more

Open Access

https://doi.org/10.1016/j.tibs.2020.03.012

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Journal: Trends in biochemical sciences	Publication Date: Apr 13, 2020
Citations: 4	License type: cc-by

Affiliation: University of Birmingham

Abstract

Nonclassical class I MHC-like molecules are ligands for several unconventional T cell populations. Recently, Le Nours et al. identified human γδ T cells recognising MHC-related protein-1 (MR1) via their T cell receptor (TCR). Also recognised by the αβ-TCR of mucosal associated invariant T cells, MR1 interacts with specific γδ-TCRs using strikingly diverse binding modes, suggesting fundamental differences in γδ T cell recognition.

Highlights

Γδ T cells, defined by their surface expression of paired γ and δ T cell receptor (TCR) chain heterodimers, have been retained throughout vertebrate evolution and play critical roles in host immunity in diverse settings, including infection, antitumour immunity, and immune regulation [1,2]
While recent evidence has confirmed butyrophilin/ butyrophilin-like (BTN/BTNL) family molecules as direct TCR ligands for γδ T cell populations bearing specific TCRγ chain variable regions, the mouse nonclassical class I MHC molecules T10 and T22 were the first γδ-TCR ligands to be confirmed biochemically [7]
The semi-invariant, innate-like Vγ9Vδ2 T cell subset, which bears a highly restricted TCR repertoire, was not a source of MHCrelated protein-1 (MR1)-specific γδ T cells. These features closely mirror those of CD1dspecific γδ T cells, but contrast with properties of invariant natural killer T cells (iNKTs) and mucosa associated invariant T cells (MAITs)

Summary

Introduction

Γδ T cells, defined by their surface expression of paired γ and δ T cell receptor (TCR) chain heterodimers, have been retained throughout vertebrate evolution and play critical roles in host immunity in diverse settings, including infection, antitumour immunity, and immune regulation [1,2]. Recognised by the αβ-TCR of mucosal associated invariant T cells, MR1 interacts with specific γδ-TCRs using strikingly diverse binding modes, suggesting fundamental differences in γδ T cell recognition.

Results

Conclusion