γδ T cells come to the fore

Abstract

Tumor Immunology Studies on T cells within the tumor microenvironment have largely focused on T cells that express γδ T cell receptors (TCRs). Benveniste et al. used an in vitro culture system to expand melanoma antigen–specific T cells and identified γδ T cells that recognize melanoma antigens in a class I major histocompatibility complex (MHC)–restricted manner. They then crystallized one of these γδ TCRs complexed with cognate peptide, MHC, and β2 microglobulin. T cell–centric therapies have been successful in treating certain cancers. These results should contribute toward a closer examination of the role of γδ T cells in the tumor microenvironment of melanomas and other cancers. Sci. Immunol. 3 , eaav4036 (2018).