γ-Selective Pd-Catalyzed Cross-Coupling of Allylboronic Acids with Iodobenzenes

Abstract

The formation of branched allylarenes by the cross-coupling reaction between allylboronic acids and aryl halides is a highly attractive process. There is a good chance for the development of its enantioselective variant, a potentially very useful synthetic method. Since allylic boronic acids are only marginally stable, the authors have designed a protocol allowing their simple preparation and direct use in the following reaction. This method gives an easy approach to various substituted allyl arenes, and represents a significant extension of the Suzuki reaction.