Abstract
In the present study, the anti-wrinkle effects of an extract of Rosa multiflora were assessed to determine whether it can be used as a heat aging-prevention cosmetic. High-performance liquid chromatography (HPLC) was used to determine the content of astragalin (the active ingredient) in the extract. The protein expression levels of MMP-1, procollagen, and transient receptor potential vanilloid (TRPV-1), which is a heat receptor thermal aging inhibitor, were measured. The protein expression of RMA, which has the best anti-wrinkle effect, was also measured. Consequently, the anti-wrinkle and heat-aging inhibition effects of R. multiflora extract and the content of astragalin resulting from each extraction condition were confirmed. Additional research is needed to verify whether astragalin has a direct effect on heat aging. However, the potential of astragalin as a heat aging-inhibitor is apparent considering the results of previous studies that have demonstrated that R. multiflora extract has excellent antioxidant activity and that R. multiflora extract inhibits the expression of certain proteins. Therefore, R. multiflora extract is a potentially useful cosmetic for the prevention or alleviation of wrinkles and heat aging.
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