Цитогенетические нарушения у больных раком легкого: феномен rogue cells в клетках крови

Abstract

In the presented «case-control» study 890 residents of the Kemerovo Region subject to age, sex, ethnicity and smoking status were included. We formed two groups: 1) «Case» - 440 newly diagnosed lung cancer patients undergoing a medical treatment in the Kemerovo Regional Oncology Center (diagnosis «lung cancer» was determined by experienced doctors from the Kemerovo Regional Oncology based on the results of special medical examination); 2) «Control» - 450 healthy donors of the Kemerovo Regional Center of Blood Transfusion. The aim of this study was the analysis chromosomal aberrations (CAs) in lung cancer patients and healthy donors resident in the same territory. The following methods were used in our investigation: the routine method of lymphocytes cultivation and chromosomal aberration analysis. Statistical analysis were performed using nonparametric statistics (Mann-Whitney U Test for paired comparison of quantitative characteristics), logistic regression. It was determined that the CAs frequency (both chromatid- and chromosome-type aberrations) was significant increased in lung cancer patients compared to control group. Furthermore in 8 lung cancer patients were found Rogue cells that were contained polycentric, ring chromosomes and multiple pair dot fragments.