Abstract
Five new metabolites including four β-resorcylic macrolides 1–4 and one octahydronaphthalene derivative 5 were isolated from a seagrass-derived fungus Fusarium sp. PSU-ES123 together with seven known compounds. Their structures were characterized by analysis of the spectroscopic data. The absolute configuration was determined by Mosher's method and circular dichroism spectroscopy. Compound 1 displayed weak antifungal activity against Cryptococcus neoformans with an MIC value of 128 μg/mL and no cytotoxic activity against noncancerous Vero cell lines. In addition, known zearalenone displayed a protective activity against INS-1 832/13 pancreatic β-cells by an EC50 value of 6.09 μM and was noncytotoxic to Vero cells.
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