Abstract
AbstractThe λ‐Radiolysis reactions of mitomycin C (1) and its derivatives were studied in the hope of developing a radiation‐induced drug (RID). The λ‐radiolysis reactions were carried out in aqueous solutions under the condition where hydrated electron (e−aq) was generated as a principal reactive species. The competitive λ‐radiolysis studies revealed that the rate constants for the reactions of 1 with e−aq at room temperature was 3.6 × 1010 dm3 mol−1s−1. Among mitomycin C derivatives, the 5H‐6‐alkoxyimino derivatives 11 and 12, and compound 13 in which ring A of 1 has the 4‐hydroxy‐6‐hydroxyimino structure cleaved to give 1. The mechanic aspect of these λ‐radiolysis reactions is discussed.
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