Abstract
Purpose. To present the results of PACK (Photo-Activated Chromophore for Keratitis) treatment of infectious keratitis with ineffective drug therapy using the example of clinical cases. Material and method. Under observation were 6 patients aged 28–55 years (5 men and 1 woman) with infectious keratitis (bacterial, viral-bacterial, acanthamoeba-bacterial, fungal). All of them received no effect within 5 weeks – 2.5 months. drug therapy (local and systemic) at the place of residence. All patients underwent PACK crosslinking. Results. Complete relief of the process was observed in all patients within 4–7 weeks (on average, after 39.2 days). As a result of treatment, in half of the patients (3 out of 6) visual acuity increased to 0.4–0.8, in 3 patients it did not change significantly after treatment and corresponded to light perception with the correct projection of light – 0.01–0.02, since the inflammatory process ended with severe corneal clouding. Conclusion. Corneal PACK crosslinking appears to be an effective and promising technique for the treatment of infectious keratitis resistant to ongoing drug therapy. In cases of the outcome of the infectious process with the formation of persistent and pronounced clouding (thorn) in such patients in the «cold» period after the arrest of the infectious process, keratoplasty with an optical purpose can be performed. Key words: infectious keratitis, drug therapy failure, PACK crosslinking, optic keratoplasty
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