μ-Oxamido binuclear copper (II) complexes: Synthesis, crystal structure, DNA interaction and antibacterial studies

Abstract

Four binuclear copper (II) complexes [Cu(oxpn)Cu(B)]2+ (2–5) bridged by N, N′-bis[3-(methylamino) propyl] oxamide (oxpn), where, B is N, N-donor heterocyclic bases (viz. 2,2′-bipyridine (bpy, 2), 1,10-phenathroline (phen, 3), dipyrido[3,2-d:2′,3′-f]quinoxaline (dpq, 4) and dipyrido[3,2-a:2′,3′-c]phenazine (dppz, 5) are synthesized, characterized by different spectroscopic and single crystal X-ray data technique. The phen (3) and dpq (4) complexes were structurally characterized by X-ray data analysis. Their DNA binding, oxidative cleavage and antibactirial activities were studied. The dpq (4) and dppz (5) complexes are avid binders to the Calf thymus DNA (CT-DNA). The phen (3), dpq (4) and dppz (5) complexes show efficient oxidative cleavage of supercoiled DNA (SC DNA) through hydroxyl radical (OH) pathway in the presence of Mercaptopropionic acid (MPA).