腺癌中 OV-6 和CD44 蛋白質的表現在腫瘤進展之意義

Abstract

Background: OV-6 is one of the markers of liver stem cells which function as liver cells repairing and bile ductal cells differentiation. Previous researches have shown patients expressed with OV-6 as a marker of cancer stem cell in liver cancer. Some studies showed that colorectal cancer can also display OV-6 expression, but it was still unclear performance in other cancers. According to previous studies, cell surface adhesion protein CD44 was widely distributed and involved many biological reactions such as: cell-to-cell and cell-to-matrix interactions, lymphocyte return, cancer cell metastasis, and function of message delivery. Materials and methods: We collected 40 cases of breast cancer, 30 cases of lung cancer, 30 cases of gastric cancer and 40 cases of colorectal cancer of adenocarcinoma. Immunohistochemical staining was performed formalin-fixed paraffin-embedded sections of variable cancers. We analyze the expression of OV-6 and CD44 with clinic and pathological data and the correlation between OV-6 and CD44 expression of breast, lung , gastric and colorectal cancer. Results: Our study found that the expression of OV-6 was significant with 8 distant metastases in the gastric cancer (P=0.014) and lymph node involvement, perineural invasion and depth of invasion in colorectal cancer (P=0.047, P=0.023 and P=0.016). The correlation between OV-6 and CD44 expression of breast cancer (P=0.001) was significant. Conclusion: OV-6 expression affects the invasion and metastasis in gastric cancer and colorectal cancer. This study intends to show that OV-6 expression can also appear in variable cancer tissues, except hepatocellular carcinoma, and some clinical behaviors were correlate with OV-6 expression. Therefore, the expression of OV-6 may be a progression predictive marker in gastric and colorectal cancers.