Abstract
The effect of γ-Oryzanol on hyperlipidemia in two types of hypothalamic obese rats, one was produced by electrical lesions of ventromedial hypothalamus (VMH) and another, monosodium glutamate (MSG)-induced lesions of arcuata and ventromedial hypothalamus, was investigated. It was found that 1) γ-Oryzanol improved hypercholesterolemia both in electrical VMH lesioned rats and MSG treated rats fed a cholesterol contained diet by feeding continuously before established obesity. It also tended to improve hypercholesterolemia in MSG treated rats fed a cholesterol contamed diet by feeding after established obesity. The improvements of hypercholesterolemia were accompanied by reduced serum alkaline phosphatase and γ-GTP and 2) γ-Oryzanol did not improve hypertriglyceridemia in MSG treated rats fed a cholesterol contained diet, however ameliorated fat deposition in liver. The results were discussed in connection with the possible mechanism of reduction of serum cholesterol and anti-fatty liver action by γ-Oryzanol.
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