Abstract
Histamine and the mast cell degranulator, compound 48/80 produced elevations in short-circuit current, an electrical measure of active anion secretion, across porcine ileal mucosa sheets mounted in Ussing chambers. Luminally-applied β-lactoglobulin produced similar effects in mucosal sheets from cow’s milk-sensitized pigs. Their secretory effects were attenuated by blockers of H 1-histamine receptors, neuronal conduction or epithelial Na +/K +/Cl − cotransport. The δ-opioid agonist [ d-Pen 2, d-Pen 5]enkephalin suppressed mucosal responses to these substances in a naltrindole-reversible manner. Furthermore, submucosal mast cells and δ-opioid receptor-immunoreactive nerve fibers were observed in close juxtaposition. Intestinal neural pathways linking immediate hypersensitivity to secretory host defense appear to express inhibitory δ-opioid receptors.
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