Abstract
In order to determine affinities at the μ opioid receptor binding was conducted to intact SH-SY5Y neuroblastoma cells using the μ-selective ligand [ 3H][H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH 2] ([ 3H]CTOP). Binding appeared to be to a single receptor site, and a single state of the μ receptor. Under intact cell conditions, some but not all μ agonists display low affinity binding, while antagonists maintain high affinity for the μ receptor. These studies indicate the usefulness of [ 3H]CTOP for the determination of affinities at the μ receptor under physiological conditions.
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