АССОЦИАЦИЯ ПОЛИМОРФИЗМОВ ГЕНОВ NOS3 И ITGB3 C РИСКОМ РАЗВИТИЯ ИШЕМИЧЕСКОЙ БОЛЕЗНИ СЕРДЦА

Abstract

The aim of the study was to evaluate the association of the polymorphism of T(786C of NOS3 gene and the polymorphism of T1565C of ITGB3 gene with the risk of development and progression of coronary artery disease in the population of the West Siberian region. The study included 242 patients with coronary artery disease (CAD), residing in the territory of the West Siberian region. The control group consisted of 162 residents of Tomsk without cardiovascular and chronic diseases. Genetic testing was performed by allele(specific PCR using SNP(express commercial kit (Lytech Company, Russia). Genotype distribution was assessed by a Pearson’s chi(square test (χ2) or Fisher’s exact test. A p(value <0.05 was considered to denote statistical significance. The genotype (786CC and the allele (786C of NOS3 gene were more common among patients with CAD than in the group of healthy volunteers (p=0.017 and p=0.007). The odds ratio for (786C allele was 1.51 [95% CI: 1.12–2.04]. Functional class (FC) III angina was most prevalent among carriers of the genotype (786CC compared with subgroups of (786TT and (786TC genotypes (p=0.044). Patients with genotype (786TC (p=0.033) had the lowest left ventricular ejection fraction. The allele 1565C of ITGB3 gene was more common among patients with CAD (p = 0.025), and the odds ratio developing CAD for 1565C allele is equal to 1.58 [95% CI: 1.06–2.35]. The allele (786C of polymorphism T(786C (NOS3) and the allele 1565C of polymorphism T1565C (ITGB3) were associated with the risk of CAD among the inhabitants of the West Siberian region. Patients with the genotype (786CC of NOS3 gene constitute the group of the risk for angina progression.